Griezmann made his debut in the Spanish first division on 29 August 2010, in the season's first match. In a post-game interview, he described the occasion as "fulfilling his childhood dream". In the team's first match after the September international break, Griezmann assisted on the equalising goal scored by Raúl Tamudo against Real Madrid. Madrid later won the match 2–1 following a goal from Cristiano Ronaldo. On 25 October, Griezmann scored his first goal in the league in a 3–0 victory over Deportivo de La Coruña. He celebrated the goal by pretending to drive a truck that was parked near the field. A week later, Griezmann scored the opening goal in a 2–1 win over Málaga. In November 2010, Griezmann scored the only goal in the team's 2–1 loss to Hércules. In the team's second match of the new year, he netted the second goal in the team's 4–0 victory over Getafe. After going scoreless in the next nine matches, Griezmann returned to his scoring form in March netting the only goal for Txuri-urdin in the team's 2–1 defeat to Racing Santander.